Addicsin, Mouse (-GTRAP3-18)

Catalogue number: ADD001

Product Type Primary Antibodies
Units25 µg
HostRabbit
Application Immunocytochemistry
Immunofluorescence
Immunohistochemistry
Western Blotting

Background
Addicsin (also named GTRAP3-18) was identified as a novel gene upregulated in mouse amygdala with morphine tolerant and dependent state (Ref.1,2). On the other hand, GTRAP3-18 is a newly identified protein of its rat homolog, which encodes a putative modulator of neural glutamate-transporter EAAC1. Addicsin is involved in regulating glutamate content in brain and it might be a key molecule of neuroplasticity and the neuropathology of addiction of drug, dementia, epilepsy, etc. Mouse Addicsin (GTRAP3-18).

Source

Immunogen: Partial peptide of mouse addicsin

Product
Affinity chromatography purified antibody in PBS with Block Ace as stabilizer and 0.1% Proclin as bacteriostat

Purification Method: Affinity chromatography purified antibody in PBS with Block Ace as stabilizer and 0.1% Proclin as bacteriostat

Concentration: 250 µg/ml

Secondary Reagents: Anti-Rabbit IgG conjugates

Specificity

Species Reactivity: Mouse

Applications
IC, IF, IHC, WB

Working Concentration: (liquid conc.) WB 1-5 µg/ml, IHC 0,5-2 µg/ml

Positive Control: Mouse brain (ddY strain)

Storage
-20°C

Caution
*These antibodies are intended for in vitro research use only. They must not be used for clinical diagnostics and not for in vivo experiments in humans or animals.

References
1. Hata T, Furukawa T, Sunamura M, Egawa S, Motoi F, Ohmura N, Marumoto T, Saya H, Horii A. (2005) RNA interference targeting aurora kinase a suppresses tumor growth and enhances the taxane chemosensitivity in human pancreatic cancer cells. Cancer Res. 65(7):2899-905. 2. Saori Akiduki , Tomoyo Ochiishi , Mitsushi J. Ikemoto (2007) Neural localization of addicsin in mouse brain. Neurosci Lett. 2007 Oct 22;426(3):149-54. 3. Akiduki S, Ikemoto MJ. (2008) Modulation of the neural glutamate transporter EAAC1 by the addicsin-interacting protein ARL6IP1. J Biol Chem. 2008 Nov 14;283(46):31323-32.