CD1a, human (MTB1)Catalog number: CD1A-MTB
Clone MTB1 labels cortical thymocytes, Langerhans-Cells in the skin as well as interdigitating cells in the dermis and in squamous epithelia of tonsils. It labels also a small group of cells outside the germinal center of tonsils, which indicates a possible cross-reactivity with CD1b. Up to now CD1 has been identified as five different variants encoded by 5 different genes (they are designed as CD1a, b, c, d and e). CD1 is exprimed by cortical thymocytes, Langerhans cells in epithelia and dendritic cells. Usually it doesn't occur in mature peripheral blood cells, but is exprimed intra-cytoplasmatically in activated T-cells. CD1a plays a role in the detection of graft versus host reaction, in the detection of interdigitating cells in artereosclerotic lesion and in asthmatic inflammation. Human CD1a, possible cross-reactivity with CD1b.
Immunogen: Recombinant protein corresponding to full length extracellular CD1a domain
Cell culture supernatant containing 0.09% sodium azide as preservative
Purification Method: Cell culture supernatant containing 0.09% sodium azide as preservative
Secondary Reagents: We recommend the use of BIOLOGO's Universal Staining System DAB (Art. No. DA005) or AEC (Art. No. AE005).
Species Reactivity: Human
Incubation Time: 60 min at RT
Working Concentration: (liquid conc.) 1:20-1:40
Pre-Treatment: Pre-treatment of formaldehyde-fixed material should be treated with Unmasking Solution E, TRIS-buffered EDTA pH 9 (Art. No. DE006) at 96-100°C
Positive Control: Thymus
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. It may contain hazardous ingredients. Please refer to the Safety Data Sheets (SDS) for additional information and proper handling procedures. Dispose product remainders according to local regulations.This datasheet is as accurate as reasonably achievable, but Exalpha Biologicals accepts no liability for any inaccuracies or omissions in this information.
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