Progesterone Receptor (ZR4)Catalog number: PR004-G
For the evaluation of prognosis and hormone dependency of mamma carcinoma oestrogen and progesterone receptors are determined in the affected tissues. Progesterone receptors are regulated by oestrogens. The antibody to progesterone receptor is well suited to detect the nuclear receptor proteins in appropriate processed tissue sections. For evaluation of prognosis it should always be used in parallel with the determination of oestrogen receptor, EGF receptor, cathepsin D and all relevant clinical factors. Cells and tissues, which are stimulated by the steroid hormone progesterone exhibit specific receptor proteins in their cell nuclei, binding the hormone and transducing the signal. Among these cells are epithelial cells of the uterine myometrium as well as normal and hyperblastic epithelial cells of the breast glands. Human progesterone receptor protein .
Immunogen: Recombinant fragment of human progesterone receptor aa 412-526
Antibody solution in stabilizing phosphate buffer pH 7.3. Contains 0.09 % sodium azide**.
Purification Method: Antibody solution in stabilizing phosphate buffer pH 7.3. Contains 0.09 % sodium azide**.
Species Reactivity: Human
Incubation Time: 60 min at RT
Working Concentration: (RTU) neat
Pre-Treatment: Pre-treatment using high temperature unmasking methods e.g. with citrate buffer (Art. No. DE000) or TRIS/EDTA (Art.-No. DE006)
Positive Control: Lobular and tubular mamma carcinoma
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. It may contain hazardous ingredients. Please refer to the Safety Data Sheets (SDS) for additional information and proper handling procedures. Dispose product remainders according to local regulations.This datasheet is as accurate as reasonably achievable, but Exalpha Biologicals accepts no liability for any inaccuracies or omissions in this information.
1. Stewart J., King R., Hayward J., et al. (1982) Oestrogen and progesterone receptors: correlation of response rates, sites and timing of analysis. Breast Cancer Research and Treatment 2; 243-252. 2.. Clark G.M., McGuire W.L., Hubay C.A. et al. (1983) Progesterone receptors as a prognostic factor in stage II breast cancer. The New England J. Med. 309(22); 1343-1347. 3. Giri D.D., Goepel J.R., Rogers K., et al. (1988) Immunohistological demonstration of progesterone receptor in breast carcinomas: correlation with radioligand binding assays and oestrogen receptor immunohistology. J. Clin. Pathol. 41; 444-447. 4. Kell D.L., et al. (1993) Immunohistochemical analysis of breast carcinoma estrogen and progesterone receptors in paraffin-embedded tissue: Correlation of clones ER 1D5 and 1A6 with a cytosol-based hormone receptor assay. Appl. Immunohistochem. 1(4); 275 ff.
Safety Datasheet(s) for this product: