Catalogue

Background
Inhibitory cell surface receptor involved in the regulation of T-cell function during immunity and tolerance. Upon ligand binding, inhibits T-cell effector functions in an antigen-specific manner. Possible cell death inducer, in association with other factors.

Synonyms: CD279, PD1

Source

Immunogen: Synthetic peptide derived from the human PD1 protein.

Product

Product Form: Affinity Purified

Formulation: Provided as solution in phosphate buffered saline with 0.08% sodium azide

Purification Method: Antigen Immunoaffiinity Purification

Concentration: See vial for concentration

Applications
Antibody can be used for immunohistochemistry (2-4 µg/ml) and Western blotting (1-2 µg/ml). Optimal concentration should be evaluated by serial dilutions.

Functional Analysis: Western Blotting

Positive Control: Human kidney

Storage
Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Product Stability: See expiration date on vial

Shipping Conditions: Ship at ambient temperature, freeze upon arrival

Caution
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. It may contain hazardous ingredients. Please refer to the Safety Data Sheets (SDS) for additional information and proper handling procedures. Dispose product remainders according to local regulations.This datasheet is as accurate as reasonably achievable, but our company accepts no liability for any inaccuracies or omissions in this information.

References
1. Shinohara, T., et al. ‘Structure and chromosomal localization of the human PD-1 gene (PDCD1)” Genomics, 23, 704-706 (1994) 2. Fife, B.T., Pauken, K.E. ‘The role of the PD-1 pathway in autoimmunity and peripheral tolerance.” Ann. N.Y. Acad. Sci., 1217, 45-59 (2011)

Protein Reference(s)

Database Name: SwissProt

Accession Number: Q15116

Species Accession: Human

Safety Datasheet(s) for this product: